Apoptosis, Annexin A5 and Anti-Annexin A5 Antibodies in The Antiphospholipid Syndrome
نویسندگان
چکیده
منابع مشابه
Anti-annexin A5 antibodies in women with spontaneous pregnancy loss.
BACKGROUND AND OBJECTIVE The aim was to evaluate the role of anti-annexin A5 (anti-ANXA5) antibodies as risk factor for recurrent miscarriage (RM) and unexplained fetal loss (UFL). PATIENTS AND METHODS Retrospective, cohort study. SETTING Vall d'Hebron University Hospital. SUBJECTS 122 women, in two groups: STUDY GROUP 54 women with RM/UFL and control group: 68 pregnant without RM/UFL. ...
متن کاملAnnexin A5 stimulates autophagy and inhibits endocytosis.
Macroautophagy is a major lysosomal catabolic process activated particularly under starvation in eukaryotic cells. A new organelle, the autophagosome, engulfs cytoplasmic substrates, which are degraded after fusion with endosomes and/or lysosomes. During a shotgun proteome analysis of purified lysosomal membranes from mouse fibroblasts, a Ca(2+)-dependent phospholipid-binding protein, annexin A...
متن کاملResistance to annexin A5 anticoagulant activity in women with histories for obstetric antiphospholipid syndrome.
OBJECTIVE The objective of the study was to investigate whether resistance to annexin A5 anticoagulant activity (AnxA5) occurs in women with histories for obstetric complications of antiphospholipid syndrome (Obs-APS) and whether this correlates with antibody recognition of domain 1 of β2-glycoprotein. STUDY DESIGN One hundred thirty-six women with antiphospholipid antibodies, including 70 wi...
متن کاملImpaired Osteoblast Differentiation in Annexin A2- and -A5-Deficient Cells
Annexins are a class of calcium-binding proteins with diverse functions in the regulation of lipid rafts, inflammation, fibrinolysis, transcriptional programming and ion transport. Within bone, they are well-characterized as components of mineralizing matrix vesicles, although little else is known as to their function during osteogenesis. We employed shRNA to generate annexin A2 (AnxA2)- or ann...
متن کاملAnnexin A5 Binds to Lipopolysaccharide and Reduces Its Endotoxin Activity
UNLABELLED Annexin A5 (AnxA5) has a high affinity for phosphatidylserine. The protein is widely used to detect apoptotic cells because phosphatidylserine, a phospholipid that is normally present in the inner leaflets of cytoplasmic membranes, becomes translocated to the outer leaflets during programmed cell death. Here we report the novel observation that AnxA5 binds to Gram-negative bacteria v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medical Biochemistry
سال: 2013
ISSN: 1452-8266,1452-8258
DOI: 10.2478/jomb-2013-0014